Welcome to the Amira-Avizo Software Use Case Gallery

Below you will find a collection of use cases of our 3D data visualization and analysis software. These use cases include scientific publications, articles, papers, posters, presentations or even videos that show how Amira-Avizo Software is used to address various scientific and industrial research topics.

Use the Domain selector to filter by main application area, and use the Search box to enter keywords related to specific topics you are interested in.

Advanced multi-scale characterization of loess microstructure: Integrating μXCT and FIB-SEM for detailed fabric analysis and geotechnical implications

Advanced multi-scale characterization of loess microstructure: Integrating μXCT and FIB-SEM for detailed fabric analysis and geotechnical implications

3D loess microstructure of loess, including skeleton particles as well as inter-particle bonding structures, was characterized through a correlative approach using μXCT and FIB-SEM

Loess, a Quaternary wind-blown deposit, is a problem soil that gives rise to frequent geohazards such as landslides and water-induced subsidence. The behavior of loess is controlled by its microstructure, consisting of silt sized
skeleton particles and complex bonding structures formed by clay-sized p... Read more

B. Yu, T.A. Dijkstra, W. Fan, I.J. Smalley, Y.N. Wei, L.S. Deng

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3D micro-structural changes of an artificial flow channel in wellbore cement under geologic CO2 storage conditions: Combined effect of effective stress and flow

3D micro-structural changes of an artificial flow channel in wellbore cement under geologic CO2 storage conditions: Combined effect of effective stress and flow

Comparative experimental observations of cement with a flow channel subject to CO2-saturated brine flow by micro-CT scanning and CT image post processing.

Understanding CO2-induced micro-structural changes at the imperfections in wellbore cement is vital for assessing the risk of CO2 leakage through wellbore cement under geologic CO2 storage (GCS) conditions. To investigate the evolution of a flow channel width in cement under GCS conditions and the influence of effective stress and fl... Read more

Manguang Gan, Liwei Zhang, Yan Wang, Kaiyuan Mei, Xiaojuan Fu, Xiaowei Cheng, Mingxing Bai, Hejuan Liu, Xiaochun Li

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Experimental investigation on the physical-thermal properties of Nanan granite after air and water cooling for deep geothermal heat extraction

Experimental investigation on the physical-thermal properties of Nanan granite after air and water cooling for deep geothermal heat extraction

Deep geothermal resources have been widely acknowledged as an alternative energy so... Read more

Zhennan Zhu, Shengqi Yang, Ren Wang, Jingyu Xie, Nuocheng Tian, Hong Tian, Jun Zheng, Guosheng Jiang, Bin Dou

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Investigating microstructure evolution of lithium metal during plating and stripping via operando X-ray tomographicmicroscopy

Investigating microstructure evolution of lithium metal during plating and stripping via operando X-ray tomographicmicroscopy

Li metal is considered as the most important negative electrode active material for Li-based batteries because of its high theoretical specific capacity of 3860mAh g-1, which is an order of magnitude higher than the currently used graphite, and by being the most electropositive metal. When coupled with high-capacity cathodes, either Li insertion materials or conversion chemistries, or applied in a solid-sate configuration, a leap in energy density can be obtained. The main challenge in the di... Read more

Matthew Sadd, Shizhao Xiong, Jacob R. Bowen, Federica Marone, Aleksandar Matic

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Dynamic changes in endoplasmic reticulum morphology and its contact with the plasma membrane in motor neurons in response to nerve injury

Dynamic changes in endoplasmic reticulum morphology and its contact with the plasma membrane in motor neurons in response to nerve injury

The endoplasmic reticulum (ER) extends throughout a cell and plays a critical role in maintaining cellular homeostasis.
Changes in ER shape could provide a clue to explore the mechanisms that underlie the fate determination of neurons after
axon injury because the ER drastically changes its morphology under neuronal stress to maintain cellular homeostasis and
recover from damage. Because of their tiny structures and richness in the soma, the detailed morphology of the ER and... Read more

Mahmoud Elgendy,Hiromi Tamada, Takaya Taira, Yuma Iio, Akinobu Kawamura, Ayusa Kunogi, Yuka Mizutani, Hiroshi Kiyama

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Continuum damage micromechanics description of the compressive failure mechanisms in sustainable biocomposites and experimental validation

Continuum damage micromechanics description of the compressive failure mechanisms in sustainable biocomposites and experimental validation

In this study, the researchers investigated the compressive failure mechanisms in flax fiber composites, a promising eco-friendly alternative to synthetic composite materials, through both numerical simulations and experimental analysis. They examined the reasons behind the low compressive strength in comparison to tensile strength, focusing on the compressive-to-tensile strength ratio. A novel thermodynamically consistent continuum damage micromechanics model was introduced to capture the ev... Read more

Vedad Tojaga, Alexandros Prapavesis, Jonas Faleskog, T. Christian Gasser, Aart W. van Vuure, Sören Östlund

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Tortuosity and microstructure effects in porous media: classical theories, empirical data and modern methods

Tortuosity and microstructure effects in porous media: classical theories, empirical data and modern methods

This study provides a comprehensive review of tortuosity and its impact on the transport properties of porous media. It discusses the classical theories and equations related to tortuosity for flow, conduction, and diffusion. The study also highlights the evolution of these theories and their connection to methodologies such as tomography and 3D image analysis. In order to clarify the topic, a new classification scheme and nomenclature for different types of tortuosity are proposed. The study... Read more

Holzer, L. *1, Marmet, P. 1, Fingerle, M. 2, Wiegmann, A. 2, Neumann, M. 3, Schmidt, V. 3

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Microstructure development analysis of long-glass-fiber-reinforced polypropylene in injection molded spiral-flow

Microstructure development analysis of long-glass-fiber-reinforced polypropylene in injection molded spiral-flow

The research focuses on the fiber behavior following injection molding on a spiral-flow mold, particularly its fiber orientation behavior. The behavior of the glass fiber will be examined by altering key experiment settings, the screw speed and the back pressure, and employing different melt paths. The results show that the application of high back pressure and high screw speed decreased the fiber length but successfully increased the fiber orientation average to the flow direction. The desig... Read more

Ahmad Hafizh Ridho, Feng-Jung Cheng, Sheng-Jye Hwang

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Three-Dimensional Architecture of Glomerular Endothelial Cells Revealed by FIB-SEM Tomography

Three-Dimensional Architecture of Glomerular Endothelial Cells Revealed by FIB-SEM Tomography

Focused-ion beam-scanning electron microscopic (FIB-SEM) tomography enables easier acquisition of a series of ultrastructural, sectional images directly from resin-embedded biological samples. In this study, to clarify the three-dimensional (3D) architecture of glomerular endothelial cells (GEnCs) in adult rats, we manually extracted GEnCs from serial FIB-SEM images and reconstructed them on an Amira reconstruction software. The luminal and basal surface structures were clearly visualized in ... Read more

Yuto Kawasaki, Yasue Hosoyamada, Takayuki Miyaki, Junji Yamaguchi, Soichiro Kakuta, Tatsuo Sakai, and Koichiro Ichimura

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Multiscale reconstruction of various vessels in the intact murine liver lobe

Multiscale reconstruction of various vessels in the intact murine liver lobe

The liver contains a variety of vessels and participates in miscellaneous physiological functions. While past studies generally focused on certain hepatic vessels, we simultaneously obtained all the vessels and cytoarchitectural information of the intact mouse liver lobe at single-cell resolution. […] providing a technology roadmap for studying the fine hepatic vascular structures and their spatial relationship, which will help research into liver diseases and evaluation of medical effi... Read more

Qi Zhang, Anan Li, Siqi Chen, Jing Yuan, Tao Jiang, Xiangning Li, Qingming Luo,Zhao Feng & Hui Gon

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High-Resolution Digital Panorama of Multiple Structures in Whole Brain of Alzheimer's Disease Mice

High-Resolution Digital Panorama of Multiple Structures in Whole Brain of Alzheimer's Disease Mice

Our study placed emphasis on solving problems in processing high-throughput bright field images and made attempt in developing a method for the extraction and reconstruction of multiple structures. This will facilitate a better understanding of the cerebral anatomical features under the pathological state of AD and shows extensive application prospect in drug efficacy assessment from brain-wide level.

Simultaneously visualizing Amyloid-β (Aβ) plaque with its surrounding brain structu... Read more

Xianzhen Yin, Xiaochuan Zhang, Jingjing Zhang, Weicheng Yang, Xian Sun, Haiyan Zhang, Zhaobing Gao, Hualiang Jiang

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Three-dimensional imaging of microstructural evolution in SEM-based nano-CT

Three-dimensional imaging of microstructural evolution in SEM-based nano-CT

Scanning electron microscopy (SEM) is a powerful and versatile technique for materials characterization and present in many laboratories. The integration of an X-ray target holder and detector allows expanding the modalities of SEM by X-ray imaging. These little hardware adaptations enable radiography ... Read more

Jonas Fell, Christoph Pauly, Michael Maisl, Simon Zabler, Frank Mücklich, Hans-Georg Herrmann

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The Ebola virus VP40 matrix layer undergoes endosomal disassembly essential for membrane fusion

The Ebola virus VP40 matrix layer undergoes endosomal disassembly essential for membrane fusion

Ebola viruses (EBOVs) assemble into filamentous virions, whose shape and stability are determined by the matrix viral protein 40 (VP40). Virus entry into host cells occurs via membrane fusion in late endosomes; however, the mechanism of how the remarkably long virions undergo uncoating, including virion disassembly and nucleocapsid release into the cytosol, remains unknown. Here, we investigate the structural architecture of EBOVs entering host cells and discover that the VP40 matrix disassem... Read more

Sophie L Winter, Gonen Golani, Fabio Lolicato, Melina Vallbracht, Keerthihan Thiyagarajah, Samy Sid Ahmed, Christian Lüchtenborg, Oliver T Fackler, Britta Brügger, Thomas Hoenen, Walter Nickel Ulrich S Schwarz, Petr Chlanda

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Electrochemical recovery of lithium-ion battery materials from molten salts by microstructural characterization using X-ray imaging

Electrochemical recovery of lithium-ion battery materials from molten salts by microstructural characterization using X-ray imaging

Recycling spent lithium-ion batteries (LiBs) guarantees the conservation of important metal resources by reducing demands on raw supply and offsetting the energy and environmental costs associated with its manufacture. Employing a molten salt as a solvent for extraction affords a much greener and simpler route to metal recovery by electrochemical means. The current mechanistic understanding of the electrochemical recovery of metals in molten salts needs to be improved for the process to be op... Read more

Mateen Mirza, Wenjia Du, Lara Rasha, Steven Wilcock, Arfon H. Jones, Paul R. Shearing, Dan J.L. Brett

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Computational fluid dynamics with imaging of cleared tissue and of in vivo perfusion predicts drug uptake and treatment responses in tumours

Computational fluid dynamics with imaging of cleared tissue and of in vivo perfusion predicts drug uptake and treatment responses in tumours

Understanding the uptake of a drug by diseased tissue, and the drug’s subsequent spatiotemporal distribution, are central factors in the development of effective targeted therapies. However, the interaction between the pathophysiology of diseased tissue and individual therapeutic agents can be complex, and can vary across tissue types and across subjects. Here, we show that the combination of mathematical modelling, high-resolution optical imaging of intact and optically cleared tumour tiss... Read more

Angela d’Esposito, Paul W. Sweeney, Morium Ali, Magdy Saleh, Rajiv Ramasawmy, Thomas A. Roberts, Giulia Agliardi, Adrien Desjardins, Mark F. Lythgoe, R. Barbara Pedley, Rebecca Shipley and Simon Walker-Samuel

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Step-by-step guide to post-acquisition correlation of confocal and FIB/SEM volumes using Amira software

Step-by-step guide to post-acquisition correlation of confocal and FIB/SEM volumes using Amira software

In recent years new methodologies and workflow pipelines for acquiring correlated fluorescence microscopy and volume electron microscopy datasets have been extensively described and made accessible to users of different levels. Post-acquisition image processing, and particularly correlation of the optical and electron data in a single integrated three-dimensional framework can be key for extracting valuable information, especially when imaging large sample volumes such as whole cells or tissu... Read more

Allon Weiner

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A multianalytic investigation of weapon-related injuries in a Late Antiquity necropolis, Mutina, Italy

A multianalytic investigation of weapon-related injuries in a Late Antiquity necropolis, Mutina, Italy

Human skeletal remains from archaeological contexts occasionally present signs of traumatic injuries from weapons, revealing, for example, the degree of interpersonal violence, the type of weapon and the sequence of events of a specific historical context.

Traumatic lesions are generally analyzed using macroscopic and microscopic methods, which are not necessarily integrated in the same study. In this study, we employed a multi-analytical approach to determine i... Read more

Antonino Vazzana, Lucia Martina Scalise, Mirko Traversari, Carla Figus, Salvatore Andrea Apicella, Laura Buti, Gregorio Oxilia, Rita Sorrentino, Silvia Pellegrini, Chiara Matteucci, Lucio Calcagnile, Raffaele Savigni, Robin N.M.Feeney, Giorgio Gruppioni, Stefano Benazziah

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A statistical assessment of ductile damage in 304L stainless steel resolved using X-ray computed tomography

A statistical assessment of ductile damage in 304L stainless steel resolved using X-ray computed tomography

X-ray computed tomography (XCT) has been shown to reveal the true extent of ductile damage below the fracture surface of failed test specimens, which is often significantly underestimated when probed using 2D serial sectioning techniques and a microscope, since a single plane of material may only exhibit only a handful of resolvable voids.

In contrast XCT offers the capability to generate large datasets consisting of hundreds, if not thousands, of individually resolvable voids, where e... Read more

A. J. Cooper ; O. C. G. Tuck ; T. L. Burnett ; A. H. Sherry

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VascuViz: a multimodality and multiscale imaging and visualization pipeline for vascular systems biology

VascuViz: a multimodality and multiscale imaging and visualization pipeline for vascular systems biology

Despite advances in imaging, image-based vascular systems biology has remained challenging because blood vessel data are often available only from a single modality or at a given spatial scale, and cross-modality data are difficult to integrate.

Therefore, there is an exigent need for a multimodality pipeline that enables ex vivo vascular imaging with magnetic resonance imaging, computed tomography and optical microscopy of the same sample, while permitting imaging with complementary c... Read more

Akanksha Bhargava, Benjamin Monteagudo, Priyanka Kushwaha, Janaka Senarathna, Yunke Ren, Ryan C. Riddle , Manisha Aggarwal and Arvind P. Pathak

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Morphological evolution and internal strain mapping of pomelo peel using X-ray computed tomography and digital volume correlation

Morphological evolution and internal strain mapping of pomelo peel using X-ray computed tomography and digital volume correlation

Among natural cellular materials, pomelo peels, having a foam-like hierarchical microstructure, represent an ideal model for developing materials with high energy absorption efficiency. In this work, by combining X-ray tomographic imaging technique and digital volume correlation (DVC), in-situ stepwise uniaxial compression tests were performed to quantify the internal morphological evolution and kinematic responses of pomelo peel samples during compression.

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B.Wang, B.Pan, G.Lubineau

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Three-dimensional grain mapping of open-cell metallic foam by integrating synthetic data with experimental data from high-energy X-ray diffraction microscopy

Three-dimensional grain mapping of open-cell metallic foam by integrating synthetic data with experimental data from high-energy X-ray diffraction microscopy

The complex mechanical response of open-cell foams depends strongly on the hierarchy of length scales inherent in them, from engineering-part scale to the ligament scale through the grain scale down to the crystal-lattice scale. A first step toward understanding and predicting the coordinated mechanical response across le... Read more

Jayden C. Plumb, Jonathan F. Lind, Joseph C. Tucker, Ron Kelley, Ashley D. Spear

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