A correlative approach for combining microCT, light and transmission electron microscopy in a single 3D scenario
![A correlative approach for combining microCT, light and transmission electron microscopy in a single 3D scenario](https://usg.fei-software-center.com/backoffice/wp-content/uploads/2018/01/12983_2013_Article_261_Fig1_HTML.jpg)
In biomedical research, a huge variety of different techniques is currently available for the structural examination of small specimens, including conventional light microscopy (LM), transmission electron microscopy (TEM), confocal laser scanning microscopy (CLSM), microscopic X-ray computed tomography (microCT), and many others. Since every imaging method is physically limited by certain parameters, a correlative use of complementary methods often yields a significant broader range of information. Here we demonstrate the advantages of the correlative use of microCT, light microscopy, and transmission electron microscopy for the analysis of small biological samples.