To evaluate the ability of radiomic feature extraction and a machine learning algorithm to diferentiate between benign
and malignant indeterminate adrenal lesions on contrast-enhanced computed tomography (CT) studies.
Adrenal “incidentalomas” are adrenal lesions that are accidentally discovered during workup not related to the adrenal glands; they have an incidence as high as 5%. Small adrenal incidentalomas (<4 cm) with high attenuation values on pre-contrast CT(>10 HU) need further evaluation to calculate the absolute percentage of washout (APW). If the APW is<60%, these lesions are considered non-adenomas and commonly classifed as indeterminate adrenal lesions. Further workup for indeterminate lesions includes more complicated and expensive radiological studies or invasive procedures like biopsy or surgical resection.