Welcome to the Amira-Avizo Software Use Case Gallery

Below you will find a collection of use cases of our 3D data visualization and analysis software. These use cases include scientific publications, articles, papers, posters, presentations or even videos that show how Amira-Avizo Software is used to address various scientific and industrial research topics.

Use the Domain selector to filter by main application area, and use the Search box to enter keywords related to specific topics you are interested in.

Loss of adult skeletal muscle stem cells drives age-related neuromuscular junction degeneration

Loss of adult skeletal muscle stem cells drives age-related neuromuscular junction degeneration

Neuromuscular junction degeneration is a prominent aspect of sarcopenia, the age-associated loss of skeletal muscle integrity. Previously, we showed that muscle stem cells activate and contribute to mouse neuromuscular junction regeneration in response to denervation (Liu et al., 2015). Here, we examined gene expression profiles and neuromuscular junction integrity in aged mouse muscles, and unexpectedly found limited denervation despite a high level of degenerated neuromuscular junctions. In... Read more

Wenxuan Liu, Alanna Klose, Sophie Forman, Nicole D Paris, Lan Wei-LaPierre, Mariela Cortés-Lopéz, Aidi Tan, Morgan Flaherty, Pedro Miura, Robert T Dirksen, Joe V Chakkalakal

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Sequential dual‑drug delivery of BMP‑2 and alendronate from hydroxyapatite‑collagen scafolds for enhanced bone regeneration

Sequential dual‑drug delivery of BMP‑2 and alendronate from hydroxyapatite‑collagen scafolds for enhanced bone regeneration

The clinical use of bioactive molecules in bone regeneration has been known to have side effects, which result from uncontrolled and supraphysiological doses.

In this study, we demonstrated the synergistic effect of two bioactive molecules, bone morphogenic protein-2 (BMP-2) and alendronate (ALN), by releasing them in a sequential manner. Collagen-hydroxyapatite composite scaffolds functionalized using BMP-2 are loaded with biodegradable microspheres where ALN is encapsulated.
Th... Read more

Dongtak Lee, Maierdanjiang Wufuer, Insu Kim, Tae Hyun Choi , Byung Jun Kim , Hyo Gi Jung, Byoungjun Jeon, Gyudo Lee, Ok Hee Jeon, Hak Chang & Dae Sung Yoon

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Collagen-Based Matrices for Osteoconduction: A Preclinical In Vivo Study

Collagen-Based Matrices for Osteoconduction: A Preclinical In Vivo Study

The aim of this study was to evaluate the influence of additional hydroxyapatite (HA) in collagen-based matrices (CM) and membrane placement on bone formation in calvarial defects.

Critical size defects in the calvaria of 16 New Zealand White Rabbits were randomly treated with CM or mineralized collagen-based matrices (mCM). Half of the sites were covered with a collagen membrane. Animals were euthanized after 12 weeks of healing. The samples were studied by micro-CT and histology. New... Read more

Hiroki Katagiri, Yacine El Tawil, Niklaus P. Lang, Jean-Claude Imber, Anton Sculean, Masako Fujioka-Kobayashi and Nikola Saulacic

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On structure and mechanics of biomimetic meta-biomaterials fabricated via metal additive manufacturing

On structure and mechanics of biomimetic meta-biomaterials fabricated via metal additive manufacturing

Material synthesis techniques have been historically used to engineer the mechanical and biological properties of biomaterials. Despite the overall success of this approach in different fronts […] there are still major unaddressed challenges due to the limited range of material properties that can be obtained through such synthesis techniques […]. Recent advances in additive manufacturing (AM) have initiated a new paradigm, which could facilitate better control of mechanical and b... Read more

Maryam Tilton, Alireza Borjali, Aaron Isaacson, Kartik Mangudi Varadarajan, Guha P.Manogharan

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Nondestructive, longitudinal measurement of collagen scaffold degradation using computed tomography and gold nanoparticles

Nondestructive, longitudinal measurement of collagen scaffold degradation using computed tomography and gold nanoparticles

Biodegradable materials, such as collagen scaffolds, are used extensively in clinical medicine for tissue regeneration and/or as an implantable drug delivery vehicle. However, available methods to study biomaterial degradation are typically invasive, destructive, and/or non-volumetric. Therefore, the objective of this study was to investigate a new method for nondestructive, longitudinal, and volumetric measurement of collagen scaffold degradation. Gold nanoparticles (Au NPs) were covalently ... Read more

Tyler A. Finamore, Tyler E. Curtis, James V. Tedesco, Kathryn Grandfield, Ryan K. Roeder

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X-ray Tomographic Imaging of Tensile Deformation Modes of Electrospun Biodegradable Polyester Fibers

X-ray Tomographic Imaging of Tensile Deformation Modes of Electrospun Biodegradable Polyester Fibers

Electrospun constructs for the repair of load-bearing tissues are required to have adequate mechanical properties. However, the failure mechanisms of electrospun fibrous materials are not well understood. Existing literature focuses on failure modes of individual fibers and/or on bulk mechanical properties of whole fiber mats.

Electrospinning allows the production of fibrous networks for tissue engineering, drug delivery, and wound healing in health care. It enables the production of c... Read more

Jekaterina Maksimcuka; Akiko Obata ; William W. Sampson ; Remi Blanc ; Chunxia Gao ; Philip J. Withers ; Olga Tsigkou ; Toshihiro Kasuga ; Peter D. Lee ; Gowsihan Poologasundarampillai

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In situ studies of materials for high temperature CO2 capture and storage

In situ studies of materials for high temperature CO2 capture and storage

Carbon capture and storage (CCS) offers a possible solution to curb the CO2 emissions from stationary sources in the coming decades, considering the delays in shifting energy generation to carbon neutral sources such as wind, solar and biomass.

The most mature technology for post-combustion capture uses a liquid sorbent, amine scrubbing. However, with the existing technology, a large amount of heat is required for the regeneration of the liquid sorbent, which... Read more

Matthew T. Dunstan, Serena A. Maugeri, Wen Liu, Matthew G. Tucker, Oluwadamilola O. Taiwo, Belen Gonzalez, Phoebe K. Allan, Michael W. Gaultois, Paul R. Shearing, David A. Keen, Anthony E. Phillips, Martin T. Dove, Stuart A. Scott, John S. Dennish and Clare P. Grey

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