Welcome to the Amira-Avizo Software Use Case Gallery

Below you will find a collection of use cases of our 3D data visualization and analysis software. These use cases include scientific publications, articles, papers, posters, presentations or even videos that show how Amira-Avizo Software is used to address various scientific and industrial research topics.

Use the Domain selector to filter by main application area, and use the Search box to enter keywords related to specific topics you are interested in.

Computational fluid dynamics with imaging of cleared tissue and of in vivo perfusion predicts drug uptake and treatment responses in tumours

Computational fluid dynamics with imaging of cleared tissue and of in vivo perfusion predicts drug uptake and treatment responses in tumours

Understanding the uptake of a drug by diseased tissue, and the drug’s subsequent spatiotemporal distribution, are central factors in the development of effective targeted therapies. However, the interaction between the pathophysiology of diseased tissue and individual therapeutic agents can be complex, and can vary across tissue types and across subjects. Here, we show that the combination of mathematical modelling, high-resolution optical imaging of intact and optically cleared tumour tiss... Read more

Angela d’Esposito, Paul W. Sweeney, Morium Ali, Magdy Saleh, Rajiv Ramasawmy, Thomas A. Roberts, Giulia Agliardi, Adrien Desjardins, Mark F. Lythgoe, R. Barbara Pedley, Rebecca Shipley and Simon Walker-Samuel

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Multi-modal plasma focused ion beam serial section tomography of an organic paint coating

Multi-modal plasma focused ion beam serial section tomography of an organic paint coating

Pigment distributions have a critical role in the corrosion protection properties of organic paint coatings, but they are difficult to image in 3D over statistically significant volumes and at sufficiently high spatial resolutions required for detailed analysis. Here we report, for the first time, large volume analytical serial sectioning tomography of an organic composite coating using a xenon Plasma Focused Ion Beam (PFIB) combined with secondary electron imaging, energy dispersive X-ray (E... Read more

Zhong Xiangli, M. Grace Burke, Philip J. Withers, Zhang Xun, Zhou Xiaorong, Timothy L. Burnett, Liu Yanwen, Stuart B. Lyon, Simon R.Gibbon

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Over the rainbow? Micro-CT scanning to non-destructively study Roman and early medieval glass bead manufacture

Over the rainbow? Micro-CT scanning to non-destructively study Roman and early medieval glass bead manufacture

The usefulness of desktop Micro-CT scanners for the study of archaeological artefacts is demonstrated in a non-destructive study of manufacturing methods of Roman and Early Medieval monochrome and polychrome glass beads. Differences in glass colours show up in these scans as differences in attenuation. The presence and distribution of bubbles and various inclusions (metal, opacifier) are also well visible. Shaft shapes and patterns of bubbles inside the glass make it possible in most cases to... Read more

D.J.M.Ngan-Tillard, D.J.Huisman, F.Corbella, A.Van Nass

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Improving microstructural quantification in FIB/SEM nanotomography

Improving microstructural quantification in FIB/SEM nanotomography

Advanced nanotomographic analysis is still far from routine, and a number of challenges remain in data acquisition and post-processing. In this work, we present a number of techniques to improve the quality of the acquired data, together with easy-to-implement methods to obtain “advanced” microstructural quantifications. The techniques are applied to a solid oxide fuel cell cathode of interest to the electrochemistry community, but the methodologies are easily adaptable to a wide range of... Read more

Joshua A.Taillon, Christopher Pellegrinelli, Yi-Lin Huang, Eric D.Wachsman, Lourdes G. Salamanca-Riba

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Influence of the rheological properties on the steel fibre distribution and orientation in self-compacting concrete

Influence of the rheological properties on the steel fibre distribution and orientation in self-compacting concrete

The interest in potential applications produced with self-compacting fibre reinforced concrete continues to grow, but in practice, problems associated with an uneven distribution and orientation of fibres in the concrete structure occur. It is not clear what exactly influences uneven distribution of fibres in selfcompacting concrete (SCC) mixtures, especially during the casting and how different factors influence fibre orientation. The objective of this work was to investigate how rheological... Read more

Elena Jasiuniene, Vaidotas Cicenas, Paulius Grigaliunas, Zymantas Rudzionis, Arunas Aleksandras Navickas

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Three-dimensional and microstructural fingerprinting of gold nanoparticles at fluid-mineral interfaces

Three-dimensional and microstructural fingerprinting of gold nanoparticles at fluid-mineral interfaces

Recent studies have identified gold nanoparticles in ores in a range of deposit types, but little is known about their formation processes. In this contribution, gold-bearing magnetite from the well-documented, world-class Beiya Au deposit, China, was investigated in terms of microstructure and crystallography at the nanoscale. We present the first three-dimensional (3D) focused ion beam/scanning electron microscopy (FIB/SEM) tomography of the distribution of gold nanoparticles in nanopores i... Read more

Haoyang Zhou, Richard Wirth, Sarah A. Gleeson, Anja Schreiber, Sathish Mayanna

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Human Motor Thalamus Reconstructed in 3D from Continuous Sagittal Sections with Identified Subcortical Afferent Territories

Human Motor Thalamus Reconstructed in 3D from Continuous Sagittal Sections with Identified Subcortical Afferent Territories

Classification and delineation of the motor-related nuclei in the human thalamus have been the focus of numerous discussions for a long time. Difficulties in finding consensus have for the most part been caused by paucity of direct experimental data on connections of individual nuclear entities. Kultas-Ilinsky et al. (2011, J Comp Neurol, 519:2811-2837) showed that distribution of the isoform 65 of glutamic acid decarboxylase (GAD65), the enzyme that synthesizes inhibitory neurotransmitt... Read more

Igor Ilinsky, Andreas Horn, Perrine Paul-Gilloteaux, Pierre Gressens, Catherine Verney, Kristy Kultas-Ilinsky

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Regional diversity in the murine cortical vascular network is revealed by synchrotron X-ray tomography and is amplified with age

Regional diversity in the murine cortical vascular network is revealed by synchrotron X-ray tomography and is amplified with age

Cortical bone is permeated by a system of pores, occupied by the blood supply and osteocytes. With ageing, bone mass reduction and disruption of the microstructure are associated with reduced vascular supply. Insight into the regulation of the blood supply to the bone could enhance the understanding of bone strength determinants and fracture healing. Using synchrotron radiation-based computed tomography, the distribution of vascular canals and osteocyte lacunae was assessed in murine cortica... Read more

J.A. Núñez; A. Goring; B. Javaheri; H. Razi; D. Gomez-Nicola; E. Hesse; A.A. Pitsillides; P.J. Thurner; P. Schneider; E. Clarkin

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High resolution X-ray computed tomography: A versatile non-destructive tool to characterize CFRP-based aircraft composite elements

High resolution X-ray computed tomography: A versatile non-destructive tool to characterize CFRP-based aircraft composite elements

The aim of the current study is to propose a versatile, non-destructive inspection strategy to evaluate the structure of two different aircraft carbon fibre reinforced polymer (CFRP) -based composite configurations, which are widely used for structural elements, respectively layered composite and sandwich structure. X-ray computed tomography (CT) has been used as a flexible method for assessment of porosity levels in CFRP components in both types of configuration, permitting to investigate th... Read more

Elena Dilonardo, Michele Nacucchi, Fabio De Pascalis, Mauro Zarrelli, Cinzia Giannini

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In situ compression and X-ray computed tomography of flow battery electrodes

In situ compression and X-ray computed tomography of flow battery electrodes

Redox flow batteries offer a potential solution to an increase in renewable energy generation on the grid by offering long-term, large-scale storage and regulation of power. However, they are currently underutilised due to cost and performance issues, many of which are linked to the microstructure of the porous carbon electrodes used. Here, for the first time, we offer a detailed study of the in situ effects of compression on a commercially available carbon felt electrode. Visualisation ... Read more

Rhodri Jervis , Matt D.R. Kok , Tobias P. Neville , Quentin Meyer , Leon D. Brown , Francesco Iacoviello , Jeff T. Gostick , Dan J.L. Brett , Paul R. Shearing

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A numerical analysis of unsteady transport phenomena in a Direct Internal Reforming Solid Oxide Fuel Cell

A numerical analysis of unsteady transport phenomena in a Direct Internal Reforming Solid Oxide Fuel Cell

Growing popularity and rapid development of Solid Oxide Fuel Cells (SOFCs) stem for their potential to become a gamechanger in the field of clean power generation technologies.

In this paper, a transient microstructure-oriented numerical simulation of a planar Direct Internal Reforming Solid Oxide Fuel Cell (DIR-SOFC) is delivered. The performance criteria in a direct steam reforming for a fuel starvation scenario are analyzed in order to optimize the underlying process. The proposed t... Read more

Maciej Chalusiak, Michal Wrobel, Marcin Mozdzierz, Katarzyna Berent, Janusz S. Szmyd, Shinji Kimijima, Grzegorz Brus

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4D imaging of polymer electrolyte membrane fuel cell catalyst layers by soft X-ray spectro-tomography

4D imaging of polymer electrolyte membrane fuel cell catalyst layers by soft X-ray spectro-tomography

4D imaging – the three-dimensional distributions of chemical species determined using multi-energy X-ray tomography – of cathode catalyst layers of polymer electrolyte membrane fuel cells (PEM-FC) has been measured by scanning transmission x-ray microscopy (STXM) spectro-tomography at the C 1s and F 1s edges. In order to monitor the effects of radiation damage on the composition and 3D structure of the perfluorosulfonic acid (PFSA) ionomer, the same volume was measu... Read more

Juan Wu, Lis G.A.Melo, Xiaohui Zhu, Marcia M.West, Viatcheslav Berejnov, Darija Susac, Juergen Stumper, Adam P.Hitchcock

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Microstructural evolution and deformation behavior of Al-Cu alloys: A Transmission X-ray Microscopy (TXM) and micropillar compression study

Microstructural evolution and deformation behavior of Al-Cu alloys: A Transmission X-ray Microscopy (TXM) and micropillar compression study

A unique approach to correlating an evolving 3D microstructure in an Al-Cu alloyand its micro-scale mechanical properties has been introduced. Using these nanoscale three-dimensional microstructures derived from Transmission X-rayMicroscopy (TXM), individual contributions from different strengthening mechanisms were quantified. The spatial distribution and morphology of the individual θ′ and θ phases were seen to play an important role in influencing dislocation storage. Uniaxi... Read more

C. Shashank Kaira, Christopher Kantzos, Jason J. Williams, Vincent De Andrade, Francesco De Carlo, Nikhilesh Chawlaa

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Mesoscale characterization of local property distributions in heterogeneous electrodes

Mesoscale characterization of local property distributions in heterogeneous electrodes

The performance of electrochemical devices depends on the three-dimensional (3D) distributions of microstructural features in their electrodes. Several mature methods exist to characterize 3D microstructures over the microscale (tens of microns), which are useful in understanding homogeneous electrodes. However, methods that capture mesoscale (hundreds of microns) volumes at appropriate resolution (tens of nm) are lacking, though they are needed to understand more common, less ideal electrode... Read more

Tim Hsu, William K. Epting, Rubayyat Mahbub, Noel T. Nuhfer, Sudip Bhattachary, Yinkai Lei, Herbert M. Miller, Paul R. Ohodnicki, Kirk R. Gerdes, Harry W. Abernathy, Gregory A. Hackett, Anthony D. Rollett, Marc De Graef, Shawn Litster, Paul A. Salvador

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A multi-scale three-dimensional Cellular Automata fracture model of radiolytically oxidised nuclear graphite

A multi-scale three-dimensional Cellular Automata fracture model of radiolytically oxidised nuclear graphite

A multi-scale approach for fracture simulation, based on the Cellular Automata technique, has been developed and then applied to a nuclear graphite that is used in structural components of the UK Advanced Gas-cooled Reactors (AGR).

High resolution X-ray computed tomographs of Gilsocarbon grade
graphite, with up to 68% weight loss by radiolytic oxidation, provide quantitative descriptions of the porosity within its constitutive filler particles and their surrounding matrix. The st... Read more

Yelena Vertyagina, Thomas James Marrow

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Microstructural analysis of TRISO particles using multi-scale X-ray computed tomography

Microstructural analysis of TRISO particles using multi-scale X-ray computed tomography

TRISO particles, a composite nuclear fuel built up by ceramic and graphitic layers, have outstanding high temperature resistance. TRISO fuel is the key technology for High Temperature Reactors (HTRs) and the Generation IV Very High Temperature Reactor (VHTR) variant.

TRISO offers unparalleled containment of fission products and is extremely robust during accident conditions. An understanding of the thermal performance and mechanical properties of TRISO fuel requires a detailed knowledg... Read more

T. Lowe, R.S. Bradley, S. Yue, K. Barii, J. Gelb, N. Rohbeck, J. Turner, P.J. Withers

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Influence of Deformation and Stress between Bone and Implant from Various Bite Forces by Numerical Simulation Analysis

Influence of Deformation and Stress between Bone and Implant from Various Bite Forces by Numerical Simulation Analysis

Endosseous oral implant is applied for orthodontic anchorage in subjects with multiple tooth agenesis. Its effectiveness under orthodontic loading has been demonstrated clinically and experimentally. This study investigates the deformation and stress on the bone and implant for different bite forces by three-dimensional (3D) finite element (FE) methods. A numerical simulation of deformation and stress distributions around implants was used to estimate the survival life for implants. The model... Read more

Hsin-Chung Cheng, Boe-Yu Peng, May-Show Chen, Chiung-Fang Huang, Yi Lin, and Yung-Kang Shen

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The development of a high throughput drug-responsive model of white adipose tissue comprising adipogenic 3T3-L1 cells in a 3D matrix

The development of a high throughput drug-responsive model of white adipose tissue comprising adipogenic 3T3-L1 cells in a 3D matrix

Adipose models have been applied to mechanistic studies of metabolic diseases (such as diabetes) and the subsequent discovery of new therapeutics. However, typical models are either insufficiently complex (2D cell cultures) or expensive and labor intensive (mice/in vivo). To bridge the gap between these models and in order to better inform pre-clinical studies we have developed a drug-responsive 3D model of white adipose tissue (WAT).

Here, spheroids (680 ± 60 μm) comp... Read more

Alexander D Graham, Rajesh Pandey, Viktoriya S Tsancheva, Alessia Candeo, Stanley W Botchway, Alasdair J Allan, Lydia Teboul4, Kamel Madi, Tahkur S Babra, Louisa A K Zolkiewski, Xuan Xue, Liz Bentley, Joan Gannon, Sam N Olof and Roger D Cox

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Distribution of Serotonin-Immunoreactive Neurons in the Brain and Gnathal Ganglion of Caterpillar Helicoverpa armigera

Distribution of Serotonin-Immunoreactive Neurons in the Brain and Gnathal Ganglion of Caterpillar Helicoverpa armigera

Serotonin (5-hydroxytryptamine, 5-HT) is an important biogenic amine that acts as a neural circuit modulator. It is widespread in the central nervous system of insects. However, little is known about the distribution of serotonin in the nervous system of the cotton bollworm Helicoverpa armigera. In the present study, we performed immunohistochemical experiments with anti-serotonin serum to examine the distribution of serotonin in the central nervous system of H. armigera larv... Read more

Qing-Bo Tang, Wei-Wei Song, Ya-Jun Chang, Gui-Ying Xie, Wen-Bo Chen* and Xin-Cheng Zhao

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Multiscale Co‐reconstruction of Lung Architectures and Inhalable Materials Spatial Distribution

Multiscale Co‐reconstruction of Lung Architectures and Inhalable Materials Spatial Distribution

Pulmonary diseases, such as chronic obstructive pulmonary diseases, lower respiratory infections, and lung cancer are listed in the top ten causes of deaths globally with more than 10 million mortality per year. Apart from oral administration, the Dry Powder Inhalation (DPI) for pulmonary administration provides an important alternative route for targeted treatment of these pulmonary diseases. […] Furthermore, there is a growing demand on und... Read more

Xian Sun, Xiaochuan Zhang, Xiaohong Ren, Hongyu Sun, Li Wu, Caifen Wang, Xiaohui Ye, Peter York, Zhaobing Gao, Hualiang Jiang, Jiwen Zhang, Xianzhen Yin

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3D computational anatomy of the scaphoid and its waist for use in fracture treatment

3D computational anatomy of the scaphoid and its waist for use in fracture treatment

A detailed understanding of scaphoid anatomy helps anatomic fracture reduction and optimal screw position. Therefore, we analyzed the size and shape variations of the cartilage and osseous surface, the distribution of volumetric bone mineral density (vBMD), and if the vBMD values differ between a peripheral and a central screw pathway?

Forty-three fresh frozen hand specimens (17 females, 26 males) were analysed with high-resolution peripheral quantitative computed tomography (HR-pQCT) ... Read more

Marc-Daniel Ahrend, Teun Teunis, Hansrudi Noser, Florian Schmidutz, Geoff Richards, Boyko Gueorguiev & Lukas Kamer

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